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RAF protein kinase inhibitor AZ 628, 5 mg  

RAF protein kinase inhibitor AZ 628, 5 mg

3-(Cyano-dimethyl-methyl)-N-[4-methyl-3-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylamino)-phenyl]-benzamide

AZ 628 is a selective RAF protein kinase inhibitor

More details

PKI-AZ628-005

Availability: within 3 days

123,50 €

Background: AZ 628 is a selective RAF kinase inhibitor, showing strong selectivity for RAF kinases among a panel of 150 tested kinases; IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF.

Chemical formula: C27H25N5O2
Molecular weight: 451.52 g/mol
Purity: >99%
Solubility: Soluble in DMSO
Appearance: Off-white solid
CAS Number: 878739-06-1

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.  

References

C Montagut et al. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res. 2008, 68(12), 4853–4861.

G Hatzivassiliou et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 2010, 464, 431-435.