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c-MET protein kinase inhibitor PF 04217903 mesylate, 5 mg  

c-MET protein kinase inhibitor PF 04217903 mesylate, 5 mg

2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol methanesulfonate

PF 04217903 mesylate is an orally bioavailabe tyrosine kinase inhibitor, targeting MET (or c-MET)

More details

PKI-PF042-005

Availability: within 3 days

123,50 €

Background: PF 04217903 mesylate is an orally bioavailabe tyrosine kinase inhibitor, targeting MET (or c-MET, Ki = 6-7 nM); it selectively binds to and inhibits mesenchymal epithelial transition (low nM Ki values and >1000 fold selective relative to 208 kinases) with potential antineoplastic activity.

Chemical formula: C19H16N8O.CH4O3S
Molecular weight: 468.49 g/mol
Purity: >99%
Solubility: Soluble in 0.1N HCl(aq)
Appearance: White solid
CAS Number: 956906-93-7

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers. 

References

SL Timofeevski et al. Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry. 2009, 48(23), 5339-49.