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CaMKII protein kinase inhibitor KN 93 phosphate, 5 mg  

CaMKII protein kinase inhibitor KN 93 phosphate, 5 mg

(E)-N-(2-(((3-(4-chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate

KN 93 phosphate is an inhibitor of multifunctional Ca2+/Calmodulin-dependent protein kinase (CaMKII)

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PKI-KN93-005

Availability: within 3 days

162,50 €

Background: KN 93 phosphate is an inhibitor of multifunctional Ca2+/Calmodulin-dependent protein kinase (CaMKII; Ki value 0.37 μM for inhibition of CaMKII phosphorylating activity). In addition, KN93 also affects CaV1.3 and CaV1.2 calcium channels in a CaMKII-independent manner.

Chemical formula: C26H29ClN2O4S.H3PO4
Molecular weight: 599.03 g/mol
Purity: 99%
Appearance: White crystals
Solubility: Soluble in water and DMSO
CAS Number: 1188890-41-6

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.  

References

M Sumi et al. The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun. 1991 Dec 31;181(3):968-75.

ME Anderson et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.

L Gao et al. CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1606-10.