Products

Biaffin

Newsletter

kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
EGFR protein kinase inhibitor OSI 420, 2 mg  

EGFR protein kinase inhibitor OSI 420, 2 mg

2-(4-(3-ethynylphenylamino)-7-(2-methoxyethoxy)quinazolin-6-yloxy)ethanol

Synonyms: Erlotinib
OSI 420 is an active O-desmethyl metabolite of Erlotinib, which inhibits EGFR tyrosine kinase

More details

PKI-OSI420-002

Availability: within 3 days

136,50 €

Background: OSI 420 is an active O-desmethyl metabolite of Erlotinib, the major metabolite of Erlotinib in human plasma, which inhibits EGFR tyrosine kinase; precursor of [11C]-labelled Erlotinib for PET study.

Chemical formula: C21H21N3O4
Molecular weight: 379.41 g/mol
Purity: 98 %
Appearance: Off-white solid
Solubility: Soluble in DMSO
CAS Number: 183321-86-0

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers. 

References

A Broniscer et al. Plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite OSI-420. Clin. Cancer Res. 2007, 13(5), 1511-1515.

Y Togashi et al. Cerebrospinal Fluid Concentration of Erlotinib and its Active Metabolite OSI-420 in Patients with Central Nervous System Metastases of Non-small Cell Lung Cancer. J. Thoracic Oncol. 2010, 5(7), 950-955.

I. Bahce et al. Development of [(11)C]erlotinib positron emission tomography for in vivo evaluation of EGF receptor mutational status. Clin. Cancer Res. 2013, 19, 183-193.

NF Smith et al. Modulation of erlotinib pharmacokinetics in mice by a novel cytochromeP450 3A4 inhibitor, BAS 100. Br. J. Cancer 2008, 98, 1630–1632.

AA Memon et al. Positron Emission Tomography (PET) Imaging with [11C]-Labeled Erlotinib: A Micro-PET Study on Mice with Lung Tumor Xenografts. Cancer Res. 2009, 69(3), 873-878.

The following products could also be interesting for you: