Products

Biaffin

Newsletter

kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
IKK protein kinase inhibitor BMS 345541, 5 mg  

IKK protein kinase inhibitor BMS 345541, 5 mg

N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine hydrochloride

BMS 345541 is a cell-permeable and highly selective IKB kinase (IKK) inhibitor.

More details

PKI-BMS345-005

Availability: within 3 days

156,00 €

Background: BMS 345541 is a cell-permeable and highly selective IKB kinase (IKK) inhibitor, binds at allosteric site of the enzyme; blocks NF-kB-dependent transcription in mice; Displays ~10-fold greater selectivity at IKK-2 over IKK-1.

Chemical formula: C14H17N5.HCl
Molecular weight: 291.78 g/mol
Purity: 98 %
Appearance: Off-white solid
Solubility: Soluble in water and DMSO
CAS Number: 547757-23-3

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.  

References

JR Burke et al. BMS-345541 is a highly-selective inhibitor of IkB kinase, binds at an Allosteric site of the enzyme, and blocks NF-kB-dependent transcription in mice. J. Biol. Chem. 2003, 278(3), 1450-1456.

J Yang et al. BMS-345541 Targets Inhibitor of κB Kinase and Induces Apoptosis in Melanoma: Involvement of Nuclear Factor κB and Mitochondria Pathways. Clin. Cancer Res. 2006, 12, 950.