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GSK3 protein kinase inhibitor AR-A 014418, 5 mg  

GSK3 protein kinase inhibitor AR-A 014418, 5 mg

1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea

AR-A 014418 is a specific glycogen synthase kinase GSK-3 inhibitor.

More details

PKI-ARA014-005

Availability: within 3 days

130,00 €

Background: AR-A 014418 is a specific glycogen synthase kinase GSK-3 inhibitor; ATP-competitive. AR-A014418 inhibits tau phosphorylation at a GSK3-specific site (Ser-396) in 3T3 fibroblasts.In hippocampal slices, the compound inhibits neurodegeneration mediated by beta-amyloid peptide.

Chemical formula: C12H12N4O4S
Molecular weight: 308.31 g/mol
Purity: 99 %
Appearance: Light brown solid
Solubility: Soluble in DMSO
CAS Number: 487021-52-3

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.  

References

R Bhat et al. Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J. Biol. Chem. 2003, 278(46), 45937-45945.

TD Gould et al. AR-A 014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int. J. Neuropsychopharmacol. 2004, 7(4), 387-390.

Carter YM, et al. Cancer Biol Ther. 2014, 15(5).

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