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JNK protein kinase inhibitor AEG 3482, 10 mg  

JNK protein kinase inhibitor AEG 3482, 10 mg

6-Phenyl-imidazo[2,1-b][1,3,4]thiadiazole-2-sulfonic acid amide

AEG 3482 is an inhibitor of JNK signaling.

More details

PKI-AEG3482-010

Availability: within 3 days

130,00 €

Background: AEG 3482 is an inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis.

Chemical formula: C10H8N4O2S2
Molecular weight: 280.33 g/mol
Purity: 99 %
Appearance: Light yellow solid
Solubility: Soluble in DMSO
CAS Number: 63735-71-7

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.  

References

AH Salehi et al. AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem. Biol. 2006, 13, 213.