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RAF protein kinase inhibitor Sorafenib tosylate, 10 mg  

RAF protein kinase inhibitor Sorafenib tosylate, 10 mg

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide

Sorafenib tosylate is a small molecule inhibitor of protein kinase, targeting the Raf/Mek/Erk pathway.
Synonyms: BAY 43-9006, Nexavar

More details

PKI-SORAF-010

Availability: within 3 days

123,50 €

Background: Sorafenib tosylate / BAY 43-9006 / Nexavar is a small molecule inhibitor of protein kinase, targeting the Raf / Mek / Erk pathway.

Chemical formula: C21H16ClF3N4O3.C7H8O3S
Molecular weight: 637.03 g/mol
Purity: 99%
Appearance: Off-white solid
Solubility: Soluble in DMSO
CAS Number: 475207-59-1

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.  

References

DJ Panka et al. The Raf Inhibitor BAY 43-9006 (Sorafenib) Induces Caspase-Independent Apoptosis in Melanoma Cells. Cancer Res 2006, 66(3), 1611-1619.
 
SM Wilhelm et al. BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis. Cancer Res. 2004, 64, 7099-7109.
 
SM Wilhelm et al. The novel Raf inhibitor Bay 43-9006 blocks signaling and proliferation in BRAF mutant and wildtype melanoma and colorectal tumor cell lines. Proc. Am. Assoc. Cancer Res. 2003, 44, 106609.
 
S. S. Sridhar et al. Raf kinase as a target for anticancer therapeutics. Mol Cancer Ther. 2005, 4, 677-685.

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