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1-NM-PP1, 5 mg  

1-NM-PP1, 5 mg

1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

PP1 is a potent tyrosine kinase inhibitor (TKI) of multiple targets, such as v-Src, c-Fyn  and c-Abl.

More details

PKI-NMPP1-005

Availability: within 3 days

161,50 €

Background: NM-PP1 is a potent tyrosine kinase inhibitor (TKI) of multiple targets, such as v-Src (IC50: 1 μM), c-Fyn (IC50: 0.6 μM), c-Abl (IC50: 0.6 μM), CDK2 (IC50: 18 μM), and CaMK II (IC50: 22 μM). Addiitonally, 1-NM-PP1 is reported to be a potent and specific inhibitor of TrkB-F616A and TrkA-F592A signaling (IC50 values approx 3 nM).

Chemical formula: C20H21N5
Molecular weight: 331.41 g/mol
Purity: 99 %
Appearance: Orange-red solid
Solubility: Soluble in DMSO
CAS Number: 221244-14-0

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.  

 

References

AC Bishop et al. Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J. Am. Chem. Soc. 1999, 121 627-631 (1999).
 
X. Chen et al. A chemical-genetic approach to studying neurotrophin signaling. Neuron. 2005, 46, 13-21.
 
AC Bishop et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 2000, 407 395-401.
 
T Sugi et al. Use of the Kinase Inhibitor Analog 1NM-PP1 Reveals a Role for Toxoplasma gondii CDPK1 in the Invasion Step. Eukaryotic Cell 2010, 9(4), 667-670.
 
X Wang et al. TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain. J. Neurosci. 2009, 29(17), 5508–5515.

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