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Aurora protein kinase inhibitor MK 5108, 5 mg  

Aurora protein kinase inhibitor MK 5108, 5 mg

(1r,4r)-4-(3-chloro-2-fluorophenoxy)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexanecarboxylic acid

MK 5108 is a highly potent and selective inhibitor of Aurora A protein kinase (AurA)
Synonyms: VX 689

More details

PKI-MK5108-005

Availability: within 3 days

162,50 €

Background: MK 5108 is a highly potent and selective inhibitor of Aurora A kinase (AurA); MK5108 exhibits marked effects on the growth of tumor cells in vitro and in vivo; also enhances the antitumoractivity of Docetaxel without exacerbrating the toxicity in vivo.

Chemical formula: C22H21ClFN3O3S
Molecular weight: 461.94 g/mol
Purity: 98 %
Optical purity: Optically pure
Appearance: White solid
Solubility: Soluble in DMSO
CAS Number: 1010085-13-8

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers. 

References

T Shimomura et al. MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel. Mol. Cancer Ther. 2010, 9(1), 157-166.

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