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ACK1 tyrosine kinase inhibitor AIM 100, 5 mg  

ACK1 tyrosine kinase inhibitor AIM 100, 5 mg

(S)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine

AIM 100 is a specific inhibitor of Ack1 tyrosine kinase (also known as TNK2)

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PKI-AIM100-005

Availability: within 3 days

161,50 €

Background: AIM 100 is a specific inhibitor of Ack1 tyrosine kinase (also known as TNK2); AIM-100 inhibits Ack1 activity and also suppresses androgen receptor (AR) Tyr(267) phosphorylation and its recruitment to the ATM enhancer (Ack1/AR/ATM signaling).

Chemical formula: C23H21N3O2
Molecular weight: 371.43 g/mol
Purity: 99%
Optical purity: 98.1% e.e.
Appearance: White solid
Solubility: Soluble in DMSO
CAS Number: 873305-35-2

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers. 

References

K Mahajan et al. Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. Prostate. 2010, 70(12), 1274-1285.
 
K Mahajan et al. Ack1 mediated androgen receptor phosphorylation modulates radiation resistance in castration resistant prostate cancer. J. Biol. Chem. 2012, 287(26), 22112-22122.
 
K Mahajan, NP Mahajan. Shepherding AKT and androgen receptor by Ack1 tyrosine kinase. J. Cell. Physiol. 2010, 224, 327–333.