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ALK protein kinase inhibitor LDK 378, 5 mg  

ALK protein kinase inhibitor LDK 378, 5 mg

5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

LDK 378 is a potent, bioavailable, and selective anaplastic lymphoma kinase (ALK) inhibitor.
Synonyms: Ceritinib

More details

PKI-LDK378-005

Availability: within 3 days

143,00 €

Background: LDK 378 / Ceritinib is a potent, bioavailable, and selective anaplastic lymphoma kinase (ALK) inhibitor (IC50 value 0.2 nM) with >35 fold selectivity over InsR, IGF-1R. LDK 378 induced a dose-dependent tumor growth inhibition and tumor regression in multiple rat xenograft models.

Chemical formula: C28H36ClN5O3S
Molecular weight: 558.14 g/mol
Purity: 99 %
Appearance: Off white solid
Solubility: Soluble in 0.1N HCl(aq) and DMSO
CAS Number: 1032900-25-6

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.  

References

J. Chen et al. LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor. J. Med. Chem. 2013, 56, 5673-5674.
 
T.H. Marsilje et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(...). J. Med. Chem. 2013, 56, 5675-5690.
 
E. Ardini et al. ALK Inhibitors, a Pharmaceutical Perspective. Front Oncol. 2012, 2, 17.