Biaffin

Newsletter

kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
 IGF1R protein kinase inhibitor NT 157, 2 mg  

IGF1R protein kinase inhibitor NT 157, 2 mg

(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide

NT 157 is a unique allosteric inhibitor of IGF1R

More details

PKI-NT157-002

Availability: within 3 days

157,50 €

Background: NT 157 is a unique allosteric inhibitor of IGF1R. NT 157 promotes ERK-MAPK dependent inhibitory Ser-phosphorylation and degradation of insulin receptor substrate 1 and 2 (IRS1/2) by shifting IGF1R complexation from IRS1/2 to Shc, which results in long-term inhibition of IGF1R signaling and powerful inhibition of tumor cell growth.

Chemical formula: C16H14BrNO5S
Molecular weight: 412.26 g/mol
Purity: 99 %
Appearance: Yellow solid
Solubility: Soluble in DMSO
CAS Number: 1384426-12-3

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers. 

References

H. Reuveni et al. Therapeutic Destruction of Insulin Receptor Substrates for Cancer Treatment. Cancer Res. 2013, 73, 4383-4394.

The following products could also be interesting for you: