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AKT protein kinase inhibitor GSK 2110183 hydrochloride, 5 mg  

AKT protein kinase inhibitor GSK 2110183 hydrochloride, 5 mg

N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride

GSK 2110183 hydrochloride is a potent, reversible, selective, and orally bioavailable inhibitor of the Akt kinases
Synonyms: Afuresertib hydrochloride

More details

PKI-GSK2110-005

Availability: within 3 days

157,50 €

Background: GSK 2110183 hydrochloride / Afuresertib hydrochloride is a potent, reversible, selective, and orally bioavailable inhibitor of the Akt kinases (Ki values 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively), with some inhibitory effect on PKA and PKG1a. GSK2110183 preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation, and various cell lines derived from hematologic malignancies, in an ATP-competitive manner and with a minimal effect on glucose homeostasis.

Chemical formula: C18H17Cl2FN4OS.HCl
Molecular weight: 463.78 g/mol
Purity: 99 %
Optical purity: Optically pure
Appearance: Off-white solid
Solubility: Soluble in water and DMSO
CAS Number: 1047645-82-8

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers. 

References

M. Dumble et al. Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor. PLoS One. 2014 Jun 30;9(6):e100880.
 
A. Spencer et al. The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma. Blood. 2014 Oct 2;124(14):2190-5.

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