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PI3 kinase inhibitor D 106669, 2 mg  

PI3 kinase inhibitor D 106669, 2 mg

1-ethyl-3-(3-(p-tolylamino)pyrido[2,3-b]pyrazin-6-yl)urea

D 106669 is a highly potent and selective PI3K inhibitor, selectively inhibiting class I PI3K

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PKI-D1066-002

Availability: within 3 days

144,50 €

Background: D 106669 is a highly potent and selective PI3K inhibitor, selectively inhibiting class I PI3K (PI3Kα IC50 <10 nM, >3 log selectivity against tyrosine or serine/threonine kinases, except ERK1 and ERK2) and showed some activity in A549 (lung cancer) xenografts mouse model at oral dose of 30 mg/kg twice daily.

Chemical formula: C17H18N6O
Molecular weight: 322,36 g/mol
Purity: 98%
Appearance: Yellow solid
Solubility: Soluble in DMSO
CAS Number: 938444-93-0

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers. 

References

SM Maira et al. Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway. Future Med. Chem. 2009, 1(1), 137-155.

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