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c-MET protein kinase inhibitor AMG 208, 10 mg  

c-MET protein kinase inhibitor AMG 208, 10 mg

7-methoxy-4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methylphenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline

AMG 208 is a potent and selective inhibitor of c-MET receptor tyrosine kinase (RTK)

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PKI-AMG 208-010

Availability: within 3 days

162,50 €

Background: AMG 208 is a potent and selective inhibitor of c-MET receptor tyrosine kinase (RTK); AMG208 inhibits both ligand-dependent and ligand-independent c-MET activation. Inhibition of c-Met signaling with AMG 208 provides a potential mechanism for blocking tumor growth and survival.

Chemical formula: C22H17N5O2
Molecular weight: 383.40 g/mol
Purity: 99 %
Appearance: Off-white solid
Solubility: Read COA for solubility
CAS Number: 1002304-34-8

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers. 

References

B.K. Albrecht et al. Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase. J. Med. Chem. 2008, 51, 2879-2882.
 
A.A. Boezio et al. Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors. Bioorg. Med. Chem. Lett. 2009, 19, 6307-6312.
 
X. Liu et al. Developing c-MET pathway inhibitors for cancer therapy: progress and challenges. Trends Mol. Med. 2010, 16, 37-45.Mol. Cancer Ther. 2009, 8(12), 3181-3190.

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