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ML-9, 10 mg  

ML-9, 10 mg

1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine . HCl

Synonyms: ML-9, ML 9, ML9
inhibitor of MLCK, MSK1, S6K1 and ROCKII

More details

PKI-ML9-010

Availability: on stock

185,00 €

Background: ML-9 is an inhibitor of myosin light chain kinase (MLCK, Ki-value 3.8 µM), MSK1, S6K1 and ROCKII. Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.

Chemical formula: C15H17ClN2O2S . HCl
Molecular weight: 324.8 . 36.5 g/mol
Appearance: white solid
Solubility: soluble in water or DMSO
CAS number: 105637-50-1

Product specific literature references:

Nagatsu T, Suzuki H, Kiuchi K, Saitoh M, Hidaka H. (1987) "Effects of myosin light-chain kinase inhibitor on catecholamine secretion from rat pheochromo- cytoma PC12h cells." Biochem Biophys Res Commun. 143(3):1045-8.

Reig JA, Viniegra S, Ballesta JJ, Palmero M, Guitierrez LM (1993) "Naphthalene- sulfonamide derivatives ML9 and W7 inhibit catecholamine secretion in intact and permeabilized chromaffin cells." Neurochem Res. 18(3):317-23

Ito S, Kume H, Honjo H, Kodama I, Katoh H, Hayashi H, Shimokata K (2004) "ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis." Eur J Pharmacol. 23;486(3):325-33

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.