kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
W-7, 25 mg  

W-7, 25 mg

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide . HCl

Synonyms: W7, W 7
inhibits Ca2+ / calmodulin-regulated enzyme activities of MLCK and PDE I

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Background: W7 is a calmodulin antagonist that binds to calmodulin and inhibits Ca2+ / calmodulin-regulated enzyme activities of myosin light chain kinase (MLCK, IC50 = 51 µM) and Ca2+ / calmodulin-regulated phosphodiesterase (PDE I, IC50 = 28 µM). It is also a vascular relaxing agent which affects vascular smooth muscle actomyosin and produces relaxation of isolated rabbit arterial strips.

Chemical formula: C16H21ClN2O2S . HCl
Molecular weight: 340.9 . 36.5 g/mol
Appearance: white solid
Purity: >97%
Solubility: soluble in hot water, methanol or DMSO
CAS Number: 61714-27-0

Product specific literature references:

Hidaka H, Sasaki Y, Tanaka T, Endo T, Ohno S, Fujii Y, Nagata T. (1981) "N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation." Proc. Natl. Acad. Sci. USA 78(7):4354-7.

Hidaka H, Asano M, Tanaka T. (1981) "Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives." Mol Pharmacol. 20(3):571-8.

Inagaki M, Tanaka T, Hidaka H. (1983) "Calmodulin antagonists enhance calcium binding to calmodulin." Pharmacology. 27(3):125-9.

Itoh H, Hidaka H. (1984) "Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase." J Biochem (Tokyo). 96(6):1721-6.

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.