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Luteolin, 100 mg  

Luteolin, 100 mg


flavonoid which has has anticancer properties

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Availability: on stock

100,00 €

Background: Luteolin is a naturally occurring compound found in foods including peanut shell, parsley, artichoke leaves and celery. It is proposed that Luteolin has anticancer properties including induction of cancer cell apoptosis, cell cycle arrest, inhibition of cancer cell proliferation, and antiangiogenesis activity. Cell treatment with the flavonoid markedly diminished the extent of cellular protein phosphorylation, by effectively modulating protein tyrosine kinase (PTK) activities, including that of EGFR.

Chemical formula:C15H10O6
Molecular Weight: 286.2 g/mol
Purity:  >90%
Appearance: Yellow to light green crystal powder
Solubility: Soluble in methanol, alkaline solutions; slightly soluble in water
CAS number: 491-70-3

Product specific literature references:

Shi RX, Ong CN, Shen HM. (2005) "Protein kinase C inhibition and x-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells."  Cancer Res.65(17):7815-23.

Huang YT, Hwang JJ, Lee PP, Ke FC, Huang JH, Huang CJ, Kandaswami C, Middleton E, Lee MT. (1999) "Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor." Br J Pharmacol. 28(5):999-1010.

Lee LT, Huang YT, Hwang JJ, Lee PP, Ke FC, Nair MP, Kanadaswam C, Lee MT.(2002) "Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells. Anticancer Res. 22(3):1615-27

Shi R, Huang Q, Zhu X, Ong YB, Zhao B, Lu J, Ong CN, Shen HM.(2007) "Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization. Mol Cancer Ther. 6(4):1338-47.

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.