kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
AICAr monophosphate (ZMP), 5 mg  

AICAr monophosphate (ZMP), 5 mg

5-Aminoimidazole-4-carboxamide-1-b-D-Ribofuranosyl monophosphate

activator of AMP-activated protein kinase (AMPK)

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120,00 €

AICAr Monophosphate is the 5′-phosphorylated analog of the membrane permeable AICA-Riboside (AICAr). It mimics AMP and acts as an activator of AMP-activated protein kinase (AMPK) in vitro. Incubation of rat hepatocytes with the non-phosphorylated AICAr results in accumulation of the monophosphorylated derivative within the cell. ZMP mimics both activating effects of AMP on AMPK, i.e. direct allosteric activation of phospho-transferase activity of AMPK.

Molecular weight 338.2 g/mol. Appearance: Off-white solid. Purity: <95%, Solubility: soluble in water. Formula C9H15N4O8P. CAS number: 3031-94-5

Synonyms: AICA-Ribotide, ZMP

Product specific literature references:

Mullane K (1993) "Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury." Cardiovasc. Res. (1):43-7

Sullivan JE, Brocklehurst KJ, Beri RK et al. (1994) "Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase" FEBS Lett. 353(1):33-6

Corton JM, Gillespie JG, Hawley SA, Hardie DG (1995) "5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?" Eur J Biochem. 229(2):558-65

Nawarskas JJ. (1999) "Acadesine: a unique cardioprotective agent for myocardial ischemia." Heart Dis. (4):255-60.

Muoio DM, Seefeld K, Witters LA, Coleman RA. (1999) "AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target." Biochem. J. 338 ( Pt 3): 783-91.

Salt IP, Connell JM, Gould GW (2000) "5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes" Diabetes 49(10):1649-56

Buhl ES, Jessen N, Lund S et al. (2002) "Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome" Diabetes 51(7):2199-206

Aschenbach WG, Hirshman MF, Goodyear LJ et al. (2002) "Effect of AICAR treatment on glycogen metabolism in skeletal muscle" Diabetes 51(3):567-73

Gadalla AE, Pearson T, Frenguelli BG et al. (2004) "AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus." J. Neurochem. 88(5):1272-82

PLEASE NOTE: Our reagents and chemicals are provided to academic institutes and pharmaceutical companies for in vitro research use only. This product has not been approved for any other purposes including, without limitation, diagnostic or therapeutic purposes, for use in preparation of food or pharmaceutical products nor for administration to humans. We do not supply private customers or non-research organizations with this product!