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PDK1 protein kinase activator PS 48, 10 mg  

PDK1 protein kinase activator PS 48, 10 mg

(Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid

PS 48 is a allosteric activator of phosphoinositide-dependent protein kinase 1 (PDPK1 or PDK1).

More details

PKI-PS48-010

Availability: within 3 days

123,50 €

Background: PS 48 is a allosteric activator of phosphoinositide-dependent protein kinase 1 (PDPK1 or PDK1). PS 48 has a Z-configuration in comparison with its inactive E-isomer PS 47.

Chemical formula: C17H15ClO2
Molecular weight: 286.75 g/mol
Purity: 99 %
Appearance: White solid
Solubility: Soluble in DMSO and Ethanol
CAS Number: 1180676-32-7

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.  

References

A Stroba et al. 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding (...). J. Med. Chem. 2009, 52(15), 4683-93.
 
V Hindie et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nature Chem. Biol. 2009, 5, 758-764.