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AKT protein kinase activator SC 79, 5 mg  

AKT protein kinase activator SC 79, 5 mg

ethyl 2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

SC 79 is a unique specific activator of cytosolic Akt (PKB)

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PKI-SC79-005

Availability: within 3 days

127,50 €

Background: SC 79 is a unique specific activator of cytosolic Akt (PKB) with the potential to recapitulate the primary cellular function of Akt signaling in a hippocampal neuronal culture system and a mouse model for ischemic stroke, resulting in augmented neuronal survival. Paradoxically, SC 79 suppressed PH-Akt-GFP plasma membrane translocation.

Chemical formula: C17H17ClN2O5
Molecular weight: 364.78 g/mol
Purity: 98 %
Appearance: White solid
Solubility: Soluble in DMSO
CAS Number: 305834-79-1

Manufacturer:  Axon Medchem BV

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers. 

References

H Jo et al. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10581-6.
 
J Skommen et al. HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells. Leukemia Res. 2006, 30(3), 322–331.

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