PD 98059, 5 mg

Background: PD 98059 is a potent, selective and cell-permeable inhibitor of MAP kinase kinase (also known as MAPK/ERK kinase or MEK). It inhibits phosphorylation of MAP kinase by MAP kinase kinase. PD 98059 does not inhibit MAP kinase itself. The IC50 values for PD 98059-induced effects are in the 1-20 µM range for many assays.

Chemical formula: C16H13NO3
Molecular weight: 267.3 g/mol
Purity: >95%
Appearance: Yellow solid
Solubility: soluble in DMSO
CAS number: 167869-21-8

Also available predissolved at 10 mM in our MAP kinase Inhibitor Set.

Product specific literature references:

Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR (1995) "PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo" J. Biol. Chem. 270(46):27489-94

Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR (1995) "A synthetic inhibitor of the mitogen-activated protein kinase cascade" Proc Natl Acad Sci USA 92(17):7686-9

Pang L, Sawada T, Decker SJ, Saltiel AR (1995) "Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor" J. Biol. Chem. 270(23):13585-8

Dumont FJ, Staruch MJ, Fischer P, DaSilva C, Camacho R (1998) "Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production" J. Immunol 160(6):2579-89

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.