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ELK-1, 10 µg  

ELK-1, 10 µg

ETS domain-containing protein

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SUB-ELK-010

Availability: within 3 days

180,00 €

Elk-1 belongs to the ETS family of transcription factors controlling various cellular functions. Their characteristic property is the ability to form a ternary nucleoprotein complex with the serum response factor (SRF) dimer. Elk-1 ist structured by an ETS domain that binds to the the 5′-GGAA/T-3′ core motif of DNA, an activation domain targeted by kinases, a repressor domain that dampens the activity of the activation and a domain required for ternary complex formation. The transcriptional activity of Elk-1 is stimulated by phosphorylation by MAP kinases (ERK, JNK and p38) and can modulate transcription of genes by interaction with the serum response element (SRE) of the c-fos promoter.

Synonyms: ETS domain-containing protein Elk-1, ELK1, Elk-1

Protein Informations: ELK-1 (amino acids 307-428), human recombinant produced in E.Coli as a maltose binding protein (MBP) with an N-terminal polyhistidine tag and a C-terminal myc tag (EQKLISEEDL). The MW is 60 kDa. Appearance: lyophilized freeze dry powder without additives, Purity: > 95% (SDS-PAGE)

Ordering informations: shipped on blue ice

Product specific literature references:

Shaw PE, Saxton J. (2003) " Ternary complex factors: prime nuclear targets for mitogen-activated protein kinases." Int J Biochem Cell Biol. 35(8):1210-26.

Buchwalter G, Gross C, Wasylyk B. (2004) "Ets ternary complex transcription factors." Gene. 2004 Jan 7; 324:1-14.

Hsu T, Trojanowska M, Watson DK. (2004) "Ets proteins in biological control and cancer." J Cell Biochem. 1; 91(5):896-903.

Shaw PE, Saxton J. (2003) "Ternary complex factors: prime nuclear targets for mitogen-activated protein kinases." Int J Biochem Cell Biol. 35(8):1210-26.

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.