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PD 153035, 10 mg  

PD 153035, 10 mg

4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride

Synonyms: ZM 252868, PD153035, PD-153035
extremely potent inhibitor of EGFR tyrosine kinase

More details

PKI-PD153-010

Availability: within 3 days

195,00 €

Background: PD 153035 is an extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosinekinase, with an IC50 of 25 pM. It inhibits other purified tyrosine kinases only at micromolar or higher concentrations.

Chemical formula: C16H14BrN3O2 . HCl
Molecular weight: 396.7 g/mol
Solubility: soluble in DMSO
Appearance: Yellow solid
CAS number: 153436-54-5

Product specific literature references:

Fry DW, Kraker AJ, McMichael A, Ambroso LA, Nelson JM, Leopold WR, Connors RW, Bridges AJ (1994) "A specific inhibitor of the epidermal growth factor receptor tyrosine kinase" Science 265(5175):1093-5

Bridges AJ, Zhou H, Cody DR, Rewcastle GW, McMichael A, Showalter HD, Fry DW, Kraker AJ, Denny WA (1996) "Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxy-quinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor" J. Med. Chem. 39(1):267-76

Kunkel MW, Hook KE, Howard CT, Przybranowski S, Roberts BJ, Elliott WL, Leopold WR (1996) "Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice" Invest. New Drugs" 13(4):295-302

Bos M, Mendelsohn J, Kim YM, Albanell J, Fry DW, Baselga J (1997) "PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner" Clin. Cancer Res. 3(11):2099-106

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.