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Piceatannol, 10 mg  

Piceatannol, 10 mg

trans-3,3′,4,5′-Tetrahydroxystilbene, 4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol

Syk/ZAP70-specific kinase inhibitor

More details

PKI-PCTL-010

Piceatannol has been reported as a Syk/ZAP70-specific kinase inhibitor, which selectively inhibits the tyrosine phosphorylation of STAT3 and STAT5, but not of STAT1 and STAT2. It also suppresses NF-kappaB activation induced by various inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation.

Formula:  C14H12O4
Molecular Weight:  244.3 g/mol
Long Term Storage:  -20°C
Appearance:  Yellow to off-white solid.
Solubility:  soluble in DMSO, dimethyl formamide, 100% ethanol or ethyl acetate
CAS number: 10083-24-6

Product specific literature references:

Geahlen RL, McLaughlin JL (1989) "Piceatannol (3,4,3\',5\'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor" Biochem. Biophys. Res. Commun. 165(1):241-5

Oliver JM, Burg DL, Wilson BS, McLaughlin JL, Geahlen RL (1994) "Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol" J. Biol. Chem. 269(47):29697-703

Soede RD, Wijnands YM, Van Kouteren-Cobzaru I, Roos E (1998) "ZAP-70 tyrosine kinase is required for LFA-1-dependent T cell migration" J. Cell. Biol. 142(5):1371-9

Su L, David M (2000) "Distinct mechanisms of STAT phosphorylation via the interferon-alpha/beta receptor. Selective inhibition of STAT3 and STAT5 by piceatannol" J. Biol. Chem. 275(17):12661-6

Seow CJ, Chue SC, Wong WS (2002) "Piceatannol, a Syk-selective tyrosine kinase inhibitor, attenuated antigen challenge of guinea pig airways in vitro" Eur. J. Pharmacol. 443(1-3):189-96

Ashikawa K, Majumdar S, Banerjee S, Bharti AC, Shishodia S, Aggarwal BB (2002) "Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation" J. Immunol. 169(11):6490-7

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.