kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
Picropodophyllin, 1 mg  

Picropodophyllin, 1 mg


Synonyms: PPP, Picropodophyllotoxin
cell-permeable, potent and specific inhibitor of IGF-1R

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Availability: within 7 days

240,00 €

Picropodophyllin is a cell-permeable, potent, and specific inhibitor of IGF-1R both in vitro (IC50 = 1 nM) and in vivo (IC50 ≤ 60 nM). This PTK inhibitor exhibits little effect towards IR, FGFR, PDGFR and EGFR and is the first inhibitor reported to discriminate between IGF-1R and IR.

Formula: C22H22O8
Molecular Weight: 414.4 g/mol
Long Term Storage: -200C
Purity:  >95%
Appearance:  White solid.
Solubility:  Soluble in in DMSO or ethanol
CAS Number: 477-47-4

Product specific literature references:

Girnita A, Girnita L, Axelson M et al. (2004) "Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth" Cancer Res. 64(1):236-42

Vasilcanu D, Girnita A, Larsson O et al. (2004) "The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway" Oncogene 23(47):7854-62

Mazitschek R, Giannis A (2004) "Inhibitors of angiogenesis and cancer-related receptor tyrosine kinases"  Curr Opin Chem Biol. 8(4):432-41

Zhang H, Yee D (2004) "The therapeutic potential of agents targeting the type I insulin-like growth factor receptor" Expert Opin Investig Drugs 13(12):1569-77

Catrina SB, Lewitt M, Brismar K et al. (2005) "Insulin-like growth factor-I receptor activity is essential for Kaposi\'s sarcoma growth and survival" Br J Cancer 92(8):1467-74

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.