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PP2, 1 mg  

PP2, 1 mg

4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4,d]pyrimidine

Synonyms: PP-2 or AG1879
potent and selective inhibitor of the src family of tyrosine kinases (Lck, Fyn and Hck)

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PKI-PP2-001

Availability: on stock

125,00 €

Background: PP2 is a potent and selective inhibitor of the src family of tyrosine kinases. Selectively inhibits Lck (IC50 ~4nM), Fyn (IC50 ~5nM) and Hck (IC50 ~5nM) compared to other tyrosine kinases such as EGF-R (IC50 ~480nM), JAK2 (IC50 ~50µM) or ZAP-70 (IC50 ~100µM). Potent inhibitor of anti-CD3-stimulated tyrosine phosphorylation of human T-cells and subsequent IL-2 gene activation.

Chemical formula C15H16ClN5
Molecular weight: 301.8 g/mol
CAS No. 172889-27-9
Purity: >95%.
Appearance: Pale Purple Solid.
Solubility: soluble in DMSO

Also available predissolved at 10 mM in our Src Family Inhibitor Set.

Product specific literature references:

Hanke JH, Gardner JP, Dow RL, Changelian PS, Brissette WH, Weringer EJ, Pollok BA, Connelly PA (1996) "Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation" J. Biol. Chem. 271(2):695-701.

Salazar EP, Rozengurt E. (1999) "Bombesin and platelet-derived growth factor induce association of endogenous focal adhesion kinase with Src in intact Swiss 3T3 cells." J. Biol. Chem. 274(40):28371-8

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.