Biaffin

Newsletter

kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
SU 4312, 5 mg  

SU 4312, 5 mg

3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one

Synonyms: DMBI, SU4312, SU-4312
potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases

More details

PKI-SU4312-005

Availability: within 3 days

195,00 €

Background: SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 µM respectively). Selective over EGFR and c-Src tyrosine kinases.

Chemical formula: C17H16N2O
Molecular weight: 264.3 g/mol
Purity: >98%
Appearance: Orange to dark red solid
Solubility: soluble in DMSO
CAS Number: 5812-07-7

Product specific literature references:

Sun L, Tran N, Tang F, App H, Hirth P, McMahon G, Tang C (1998) "Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases" J. Med. Chem. 41(14):2588-603

Zaman GJ, Vink PM, van den Doelen AA, Veeneman GH, Theunissen HJ (1999) "Tyrosine kinase activity of purified recombinant cytoplasmic domain of platelet-derived growth factor beta-receptor (beta-PDGFR) and discovery of a novel inhibitor of receptor tyrosine kinases" Biochem. Pharmacol. 57(1):57-64

Kendall RL, Rutledge RZ, Mao X, Tebben AJ, Hungate RW, Thomas KA (1999) "Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues" J. Biol. Chem. 274(10):6453-60

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.  

The following products could also be interesting for you: