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SU 6656, 1 mg  

SU 6656, 1 mg

2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide

Synonyms: SU6656, SU-6656
potent src family kinase inhibitor (Src, Fyn, Yes and Lyn)

More details

PKI-SU6656-001

Availability: within 3 days

100,00 €

Background: SU 6656 is a potent src family kinase inhibitor and inhibits Src (IC50 = 280 nM) as well as closely related kinases such as Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). Inhibition is competitive to ATP. It acts as a weak inhibitor of Lck (IC50 = 688 µM) and PDGF receptor tyrosine kinase (IC50 >10 µM).

Chemical formula: C19H21N3O3S
Molecular weight: 371.5 g/mol
Purity: >98%
Appearance: Orange solid
Solubility: soluble in DMSO
CAS Number: 330161-87-0

Also available predissolved at 10 mM in our Src Family Inhibitor Set.

Product specific literature references:

Blake RA, Broome MA, Liu X, Wu J, Gishizky M, Sun L, Courtneidge SA (2000) "SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling" Mol. Cell. Biol. 20(23):9018-27

Bowman T, Broome MA, Jove R et al. (2001) "Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis" Proc. Natl. Acad. Sci. U S A. 98(13):7319-24

Sorkina T, Huang F, Beguinot L, Sorkin A (2002) "Effect of tyrosine kinase inhibitors on clathrin-coated pit recruitment and internalization of epidermal growth factor receptor" J. Biol. Chem. 277(30):27433-41

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.