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Tyrphostin AG 490, 25 mg  

Tyrphostin AG 490, 25 mg

N-Benzyl-3,4-dihydroxy-benzylidenecyanoacetamide; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide

Synonyms: AG490, Tyrphostin B42, AG-490
JAK-2 protein tyrosine kinase inhibitor and also inhibits EGFR tyrosine kinase autophosphorylation

More details

PKI-AG490-025

Availability: within 3 days

205,00 €

Background: Tyrphostin AG 490 is a specific and potent JAK-2 protein tyrosine kinase inhibitor and also inhibits EGF receptor autophosphorylation, with an IC50 of 100 nM.  It inhibits DNA synthesis and cell growth and induces apoptosis. Photosensitive.

Chemical formula: C17H14N2O3
Molecular weight: 294.3 g/mol
Purity: >98%
Appearance: Cream Solid
Solubility: soluble in DMSO
CAS Number: 134036-52-5

Product specific literature references:

Gazit A, Yaish P, Gilon C, Levitzki A (1989) "Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors" J. Med. Chem. 32(10):2344-52.

Gazit A, Osherov N, Posner I, Yaish P, Poradosu E, Gilon C, Levitzki A (1991) "Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases" J. Med. Chem. 34(6):1896-907

Osherov N, Gazit A, Gilon C, Levitzki A (1993) "Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins" J Biol Chem 268(15):11134-42

Meydan N, Grunberger T, Dadi H, Shahar M, Arpaia E, Lapidot Z, Leeder JS, Freedman M, Cohen A, Gazit A, Levitzki A, Roifman CM (1996) "Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor" Nature 379(6566):645-8

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.