kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
ER 27319 maleate, 10 mg  

ER 27319 maleate, 10 mg

ER 27319 maleate, Spleen tyrosine kinase (Syk) inhibitor, 10-(3-Aminopropyl)-3,4-dimethyl-9-acridone oxalate

Synonyms: ER27319
selective Syk inhibitor, CAS number: 201010-95-9

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Background: ER 27319 maleate is a Spleen tyrosine kinase (Syk) inhibitor. Selective inhibitor of Syk kinase. It inhibits tyrosine phosphorylation of Syk initiated by the engagement of FceRI in rat and human mast cells which results in the abrogation of degranulation, TNF-a production (IC50 = 10 mM) and other related signalling events.

Chemical formula: C18H20N2O.C4H4O4
Molecular Weight: 370.4 g/mol
Purity: > 98%
Appearance: yellow solid
Solubility: in DMSO: 28 mg/mL, water: to 75 mM
CAS number: 201010-95-9

Product specific literature references:

Moriya K, Rivera J, Odom S, Sakuma Y, Muramato K, Yoshiuchi T, Miyamoto M, Yamada K. (1997) " ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fcε receptor I-mediated activation of Syk." Proc.Natl.Acad.Sci.USA 94(23):1239-44.

Luskova P, Draber P. (2004) " 94, 12539-12544, (1997)"Modulation of the Fcepsilon receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases" Curr. Pharm. Des. 10(15):1727-37.

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.