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EGFR tyrosine kinase inhibitor Lavendustin A, 1 mg  

EGFR tyrosine kinase inhibitor Lavendustin A, 1 mg

5-[[(2,5-Dihydroxyphenyl)methyl][(2hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid

Synonyms: RG 14355
cell-permeable inhibitor of EGFR tyrosine kinase

More details

PKI-LAV-001

Background: Lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 11 nM). It inhibits p60c-src with an IC50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC50 > 100 mM).
Molecular Weight: 381,38 g/mol
Chemical formula: C21H19NO6
Purity: >95%
Appearance: white lyophilised film
Solubility: in DMSO/Ethanol to 25 mM
CAS number: 125697-92-9

Product specific literature:

Onoda T, Iinuma H, Sasaki Y, Hamada M, Isshiki K, Naganawa H, Takeuchi T, Tatsuta K, Umezawa K. (1989) “Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from streptomyces griseolavendus.” J.Nat.Prod. 52 1252-7.
O\'Dell TJ, Kandel ER, Grant SG.(1991) “Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors.”Nature 353 558-60.
Hsu CY, Persons PE, Spada AP, Bednar RA, Levitzki A, Zilberstein A. (1991) “Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by laven-dustin-A and its analogue.” J.Biol.Chem. 266 21105-12.

PLEASE NOTE: This product is designed for research purposes and can only be delivered to academic and business customers.

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