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Recombinant human HVEM/TNFRSF14 Protein, Fc Tag, 1mg  

Recombinant human HVEM/TNFRSF14 Protein, Fc Tag, 1mg

Recombinant Human HVEM /TNFRSF14 Protein, Pro37-Val202, produced in human 293 cells (HEK293), Fc Tag

recombinant, human protein, TNFRSF14, ATAR, HVEA, HVEM, herpesvirus entry mediator

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Availability: within 7 days

1 980,00 €

Herpesvirus entry mediator (HVEM), also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily.

HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFß (lymphotoxin a) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTßR, the receptor for lymphotoxin aß heterotrimer. The role of the HVEM LIGHT /LTß receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.[1-4]

Recombinant Human HVEM /TNFRSF14 Protein, With C-Fc Tag (rhHVEM-Fc) Pro37-Val202  (Accession # NP_003811.2) was produced in human 293 cells (HEK293)

Molecular Characterization
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 45.4 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per µg of the rhHVEM-Fc by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C-8°C); After reconstitution under sterile conditions for 1 month (4°C-8°C) or 3 months (-20°C to -70°C).

Immobilized Human LIGHT, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. LIT-H5256) at 2 μg/mL (100 μL/well) can bind Human HVEM, Fc Tag (Cat. No. HVM-H5258) with a linear range of 0.3-20 ng/mL (QC tested).
Immobilized Human HVEM, Fc Tag (Cat. No. HVM-H5258) at 5 μg/mL (100 μL/well) can bind Biotinylated Human BTLA (31-134), Fc,Avitag (Cat. No. BTA-H82F8) with a linear range of 0.156-5 μg/mL (Routinely tested).


(1) Hsu, H. et al. (1997) J. Biol. Chem. 272:13471.
(2) Mauri, D.N. et al. (1998) Immunity 8:21
(3) Montgomery, R.I. et al. (1996) Cell 87:427
(4) Cheung,T.C.etal.,2005,Proc.Natl.Acad.Sci.USA102:13218-23