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Recombinant human CNTN2 / Contactin-2 Protein, 100µg  

Recombinant human CNTN2 / Contactin-2 Protein, 100µg

Recombinant Human Contactin-2  / Tag1 / CNTN2 Protein, Ser31-Asn1012, produced in human 293 cells (HEK293), His tag

Recombinant, human protein, CNTN2, CNTN-2, AXT, TAG-1, TAG1, TAX, TAX1, TAX-1, Contactin-2

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Availability: within 7 days

455,00 €

Contactin-2 also known as CNTN2, TAX1 (transiently-expressed axonal glycoprotein), TAG1 (transient axonal glycoprotein), and axonin-1, and is a member of the immunoglobulin superfamily. CNTN2 consists of six Ig-like domains and four fibronectin type III domains, and is anchored to the membrane by glycosylphosphatidylinositol (GPI), whereas the soluble form can be released by a GPI-specific phospholipase. As a neural cell adhesion molecule expressed by a subset of neuronal populations in the developing CNS and PNS, CNTN2 mediates cell-cell interactions either via homophilic, or heterophilic contacts with various adhesion molecules including NgCAM, NrCAM, NCAM and neurocan. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.[1-3]

Recombinant Human Contactin-2 /CNTN2 Protein, His Tag (CN2-H5226) is expressed from human 293 cells (HEK293). It contains AA Ser 31 - Asn 1012 (Accession # NP_005067.1).
Predicted N-terminus: Ser 31

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 108.3 kDa. The protein migrates as 116-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.


Clinical and Translational Updates

(1) "Characterization of the patients with antibodies against nodal-paranodal junction proteins in chronic inflammatory demyelinating polyneuropathy"
Dong, Tai, Yang et al
Clin Neurol Neurosurg (2022) 223, 107521
(2) "Combined progressive functional exercise effect on contactin-1 and contactin-2 level in mildly disabled persons with multiple sclerosis"
Bilek, Ercan, Demir
Mult Scler Relat Disord (2022) 67, 104095
(3) "Putative Candidate Drug Targets for Sarcopenia-Related Traits Identified Through Mendelian Randomization Analysis of the Blood Proteome"
Chen, Wang, Meng et al
Front Genet (2022) 13, 923429
Showing 1-3 of 313 papers.