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STE group

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Recombinant protein kinases of the STE family

The STE group includes homologs of the yeast sterile kinases sterile 7, sterile 11, and sterile 20, which sequentially activate each other and MAPK members. Ste20 kinases (MAP4K) act on Ste11 kinases (MAP3K), which phosphorylates and activates dual specificity MAPK kinase (Ste7)(MAP2K, MEK, MKKs) member upstream of MAPKs of the CMGC group. The Ste20 group kinases are further divided into the p21-activated kinase (PAK) and germinal center kinase (GCK) families.

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