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CaMK group

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Recombinant Calcium/Calmodulin-dependent protein kinases

The calcium/calmodulin-dependent kinases (CaMKs) are a subfamily of serine/threonine kinases that translate and coordinate an increase of intracellular Ca2+ concentration into cellular responses via phosphorylation. The activity of this kinases is regulated primary by the Ca2+ receptor protein calmodulin (CaM). The multifunctional CAMK family is comprised of CAMKI, CAMKIV and CAMKK - all part of the so called Ca-calmodulin-dependent protein kinase cascade and the CAMKII subfamily. The dedicated kinases (which are dedicated to a single substrate) includes e.g. phosphorylase kinase, myosin light chain kinase (MLCK), and eukaryotic elongation factor-2 kinase.