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The AGC kinase group defines the subgroup of Ser/Thr...
cGMP-dependent protein kinases (PKG) are a group of Ser/Thr protein kinases containing two isoforms, type 1 and type 2, that are regulated by the second messenger cGMP. In contrast to PKA, the cGMP binding and catalytic domains are located on the same polypeptide. Binding of the second messenger cGMP induces a conformational change that relieves the inhibitory effect of a pseudosubstrate domain. PKG mediates many of the smooth muscle relaxation effects triggered by nitric oxide.
cAMP-dependent protein kinase - PKA is an ubiquitous serine-theonine protein kinase present in a variety of tissues. The intracellular cAMP level regulates cellular responses by altering the interaction between the catatytic C and regulatory R subunits of PKA. The inactive PKA holoenzyme is activated when cAMP binds to the regulatory subunits which induces the release of two active catalytic subunits.
Protein kinase B or Akt (PKB/Akt)is a serine/threonine kinase, which in mammals comprises three highly homologous members known as PKB alpha (Akt1), PKB beta (Akt2) and PKB gamma (Akt3). PKB/Akt is a growth-factor-regulated protein kinase which contains a pleckstrin homology (PH) domain. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside-dependent kinase 1 (PDK1). Key roles for this enzyme can be found in cellular processes such as glucose metabolism, cell proliferation, apoptosis, transcription and cell migration.
Recombinant human PKA catalytic subunit type alpha, (PKA C alpha), active enzyme Alternate names: PKA, cAMP-dependent protein kinase, PKA C-alpha, PKA Calpha, PKAC, PKACA, PKA-Ca, cAMP dependent protein kinase, PKA catalytic subunit alpha, cAMP-kinase, protein kinase A
Recombinant human PKA catalytic subunit type beta,(PKA C beta1), active enzyme Alternate names: PKA, cAMP-dependent protein kinase, PKA C-beta1, PKA Cbeta1, PRKCB, PKA-Cb1, cAMP dependent protein kinase, PKA catalytic subunit beta, cAMP-kinase, protein kinase A
Recombinant human PKA regulatory subunit, type I beta (PKA RI beta) Alternate names: PKA-RI beta, Prkar1b, Protein kinase A RI beta subunit, Protein kinase cAMP-dependent regulatory, type I beta, R1 beta, RI beta, RIbeta
Recombinant human cAMP-dependent protein kinase type II-alpha regulatory subunit Alternate names: PKA RII alpha, Prkar2a, PKA R2 alpha subunit, Protein kinase A type II regulatory subunit, Protein kinase A, cAPK RIIalpha, cAMP-dependent protein kinase RII subunit
Recombinant human camp-dependent protein kinase PKA regulatory subunit, type II beta Alternate names: PKA RII beta, PKA-RII beta, PKA R2 beta, PKA-R2 beta, PRKAR2B, regulatory subunit type II beta of cAMP-dependent protein kinase; cAMP-dependent protein kinase type 2 beta regulatory subunit
Recombinant human CDC42 binding protein kinase beta / CDC42BPB, active enzyme Alternate names: CDC42 binding protein kinase beta (DMPK-like), KIAA1124, CDC42-binding protein kinase beta, MRCKB, MRCK beta, DMPK-like beta, CDC42BPB
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