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recombinant proteins

There are 674 products.

Recombinant proteins

Recombinant proteins and receptors - highly pure and active recombinant proteins expressed in HEK293 cells.

  • Fc receptor proteins

    Fc Receptor Proteins 

    The efficacy of a therapeutic antibody not only depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors. The binding affinity of the Fc fragment towards FcRn (FCGRT&B2M) would predict the antibody’s half life, while that between the Fc fragment and FCGRIIIA (CD16a) would influence the antibody’s ability to elicit ADCC (antibody dependent cell mediated cytotoxicity). Hence, screening for desired binding affinity to these Fc receptors is an essential component in the development of a therapeutic mAb (monoclonal antibody).

    We offer a comprehensive collection of recombinant Fc receptor proteins of different species (human, mouse, rat, cynomolgus, porcine) including their common variants.

    FcRn / FCGRT & B2M

    Fc gamma RIIIA / CD16a

    Fc gamma RIIIB / CD16b

    Fc gamma RIIA / CD32a

    Fc gamma RIIB / CD32b

    Fc gamma RI / CD64

    CD23 / Fc epsilon RII Protein

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  • Llama IgG Fc Fusion Proteins

    Llama IgG Fc Fusion Proteins - uniquely designed for llama immunization

    The single domain antibody was originally discovered in camels back in 1993. This new class of antibody is heavy chain only, containing a single variable domain (VHH) and two constant domains (CH2, CH3). This rare form of antibody has following unique advantages, which makes it an intriguing alternative to the conventional antibodies when it comes to therapeutic use.

    First, because of its small size, these nanobodies are known to be able to reach to the cryptic epitopes of the targets normally not accessible by the much larger traditional antibodies. The stability of these antibodies is much better than the traditional antibodies, which makes it possible to be delivered through oral and maybe ocular routes, in addition to intravenous and subcutaneous injection. The nanobodies can also be easily conjugated with cell-killing agents if needed. Last but not least, from manufacturing standpoint, nanobodies are much easier to produce from a variety of hosts.

    ACROBiosystems provides a unique portfolio of llama lgG Fc tagged recombinant antigens, which are uniquely designed for llama immunization.

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  • viral proteins (SARS-Cov-2 related proteins)

    Recombinant viral proteins / SARS-CoV-2 related products

    SARS-CoV-2 is an enveloped positive-stranded RNA virus that consists of four structural proteins including spike (S) glycoprotein, envelope (E) protein, membrane (M) protein, and nucleocapsid (N) protein. Spike glycoprotein is the most important surface protein of SARS-CoV-2, which can mediate the virus entry into human respiratory epithelial cells by interacting with cell surface receptor angiotensin-converting enzyme 2 (ACE2). S, S1 and S RBD proteins are important targets in the development of SARS-COV-2 therapeutics and vaccines. The quality and application of SARS-COV-2 S, S1, S RBD and human ACE2 and other proteins are the key to the development of antiviral drugs.

    ACROBiosystems has been keeping a close eye on the development of the epidemic situation and accelerating the development of SARS-COV-2 antigen proteins, antibodies, kits and other related products to facilitate the development of serologic tests, therapeutic antibodies and vaccines. ACROBiosystems has developed over 100 products related to SARS-CoV-2, including recombinant proteins, antibodies, kits, beads and so on covering the critical targets of SARS-CoV-2.

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