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recombinant proteins

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Recombinant proteins

Recombinant proteins and receptors - highly pure and active...

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  • Fc receptor proteins

    Fc Receptor Proteins 

    The efficacy of a therapeutic antibody not only depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors. The binding affinity of the Fc fragment towards FcRn (FCGRT&B2M) would predict the antibody’s half life, while that between the Fc fragment and FCGRIIIA (CD16a) would influence the antibody’s ability to elicit ADCC (antibody dependent cell mediated cytotoxicity). Hence, screening for desired binding affinity to these Fc receptors is an essential component in the development of a therapeutic mAb (monoclonal antibody).

    We offer a comprehensive collection of recombinant Fc receptor proteins of different species (human, mouse, rat, cynomolgus, porcine) including their common variants.

    FcRn / FCGRT & B2M

    Fc gamma RIIIA / CD16a

    Fc gamma RIIIB / CD16b

    Fc gamma RIIA / CD32a

    Fc gamma RIIB / CD32b

    Fc gamma RI / CD64

    CD23 / Fc epsilon RII Protein


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