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cGMP-dependent protein kinase, PKG

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cGMP-dependent protein kinases (PKG)

cGMP-dependent protein kinases (PKG) are a group of Ser/Thr protein kinases containing two isoforms, type 1 and type 2, that are regulated by the second messenger cGMP. In contrast to PKA, the cGMP binding and catalytic domains are located on the same polypeptide. Binding of the second messenger cGMP induces a conformational change that relieves the inhibitory effect of a pseudosubstrate domain. PKG mediates many of the smooth muscle relaxation effects triggered by nitric oxide.