kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
Recombinant human Annexin A5 Protein, His Tag, 100µg  

Recombinant human Annexin A5 Protein, His Tag, 100µg

Recombinant Human Annexin A5 Protein, Met1-Aps320 produced in E.coli cells, His Tag

recombinant human protein, AN5-H5123-ANXA5, ANX5, ENX2, PP4, annexin V, Annexin A5

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Availability: within 7 days

216,00 €

Annexin A5 is a phospholipid binding protein, which binds with high affinity and selectivity to PS in the presence of calcium. PS is predominantly located in membrane leaflets, which face the cytosol. However, recent findings show that each cell type has the molecular machinery to expose PS at its cell surface. This machinery is activated during the execution of apoptosis. Once PS is exposed at the cell surface it exhibits procoagulant and proinflammatory activities. Anexin A5 will bind to the PS-exposing apoptotic cell and can inhibit the procoagulant and proinflammatory activities of the dying cell. Anexin A5 has also been identified as an anticoagulant protein in the blood coagulation cascade, by acting as an inhibitor of prothrombin activation. The presence of antibodies to Anexin A5 is associated with systemic lupus erythematosus (SLE), recurrent spontaneous abortions and systemic sclerosis (SSc). [1,2]

Recombinant Human Annexin A5 Protein (rhANXA5) Met1-Aps320 (Accession #AAH01429 ) was produced in E.coli cells.

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 36.8 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE).

Less than 1.0 EU per μg of the rhANXA5 by the LAL method.

>98% purity as determined by SDS-PAGE of reduced rhANXA5.

Lyophilized from 0.22 μm filtered solution in PBS, pH 8.0. Normally Mannitol or Trehalose are added as protectants before lyophilization.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4C-8C); After reconstitution under sterile conditions for 1 month (4C-8C) or 3 months (-20C to -70C).


(1)Adekunle I. Elegbede a, D.K. Srivastava,et al. 2006, Protein Expression and PuriWcation 50: 157–162.
(1)Bent Brachvogela, Heike Welzel, et al. 2001, Mechanisms of Development 109: 389–393.