kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
Recombinant human NTRK2 /TRKB Protein, Fc Tag, 100µg  

Recombinant human NTRK2 /TRKB Protein, Fc Tag, 100µg

Recombinant Human NTRK2 /TRKB Protein, Cys 32 - His 430 was produced in human 293 cells (HEK293), Fc Tag

recombinant human protein, NTRK2, TRKB, GP145-TrkB

More details


Availability: within 7 days

300,00 €

Neurotrophic tyrosine kinase receptor type 2 (NTRK2) also known as BDNF/NT-3 growth factors receptor, Tropomyosin-related kinase B (TRKB) and TrkB tyrosine kinase, which belongs to the protein kinase superfamily or Tyr protein kinase family. Insulin receptor subfamily. NTRK2 / TrkB contains two Ig-like C2-type (immunoglobulin-like) domains, two LRR (leucine-rich) repeats, one LRRCT domain, one LRRNT domain, one protein kinase domain. NTRK2 / Trk-B is expressed in the central and peripheral nervous system. The catalytic activity of NTRK2 is “ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate”. NTRK2 / TrkB involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity.

Recombinant Human NTRK2 /TRKB Protein, with C-Fc Tag (rhNTRK2 Fc Chimera) Cys 32 - His 430 (Accession # AAH31835) was produced in human 293 cells (HEK293).

Molecular Characterization
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 70.4 kDa. The protein migrates as 86-116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg of the rhNTRK2 Fc Chimera by the LAL method.

>98% purity as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.0. Normally Mannitol or Trehalose are added as protectants before lyophilization.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C-8°C); After reconstitution under sterile conditions for 1 month (4°C-8°C) or 3 months (-20°C to -70°C).



(1) Allen S.J., et al., 1994, Neuroscience 60:825-834.
(2) Stoilov P., et al., 2002, Biochem. Biophys. Res. Commun. 290:1054-1065.
(3) Meakin S.O., et al., 1999, J. Biol. Chem. 274:9861-9870.
(4) Yeo G.S., et al., 2004, Nat. Neurosci. 7:1187-1189.