kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
Recombinant Human BMPR-1A / ALK-3 Protein, Fc Tag, 200µg  

Recombinant Human BMPR-1A / ALK-3 Protein, Fc Tag, 200µg

Recombinant Human Bone morphogenetic protein receptor (BMPR)-1A / ALK-3 Protein, AA Gln 24 - Arg 152, expressed from human 293 cells (HEK293), Fc Tag

Synonym: recombinant, human, protein BMPR-1A, ALK-3, ACVRLK3, CD292, SKR5, bone morphogenetic protein receptor type IA

More details


Availability: within 7 days

312,00 €

The bone morphogenetic protein receptor, type IA also known as BMPR1A or ALK3 is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 290). The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2[1]. Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis[2].

Recombinant, human Bone morphogenetic protein receptor,type IA Fc Chimera (rhBMPR1A-Fc or rhALK3-Fc), Fc Tag (AL3-H5259) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Arg 152 (Accession # P36894-1).
Predicted N-terminus: Gln 24

Molecular Characterization
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 40.3 kDa. The protein migrates as 56 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>98% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Clinical and Translational Updates

(1) "Loss of bone morphogenetic protein signaling in fibroblasts results in CXCL12-driven serrated polyp development"
Ouahoud, Westendorp, Voorneveld et al
J Gastroenterol (2023) 58 (1), 25-43
(2) "Bone morphogenetic protein-4 system expression in human coronary artery endothelial and smooth muscle cells under dynamic flow: effect of medicated bioresorbable vascular scaffolds at low and normal shear stress"
Cabiati, Giacomarra, Fontanini et al
Heart Vessels (2022) 37 (12), 2137-2149
(3) "BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation"
Mang, Kleinschmidt-Doerr, Ploeger et al
J Cell Sci (2020) 133 (16)
Showing 1-3 of 42 papers.