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Recombinant Human PLGF/PIGF2/PGF Protein, His Tag, 20µg  

Recombinant Human PLGF/PIGF2/PGF Protein, His Tag, 20µg

Recombinant Human PLGF-2 / PGF Protein (rhPGF) Leu 19 - Arg 170 was produced in human 293 cells (HEK293), His tag

Recombinant Human Protein, PGF, PLGF, PlGF2, PlGF, PGFL, SHGC-10760

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Availability: within 7 days

377,00 €

Placental growth factor (PGF) also known as vascular endothelial growth factor-related protein, PLGF and PlGF2, is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PGF is actived in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. PlGF2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.

Recombinant Human PlGF Protein (rhPGF), His Tag (PGF-H5229) is expressed from human 293 cells (HEK293). It contains AA Leu 19 - Arg 170 (Accession # NP_002623.2).
Predicted N-terminus: Leu 19

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 18.2 kDa. The protein migrates as 28-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in 100 mM Acetic Acid, pH3.0 with trehalose as protectant.

Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Please refer to product data sheet.

Clinical and Translational Updates

(1) "Angiogenic imbalance in pregnancies with preterm prelabor rupture of membranes between 34 and 37 weeks of gestation"
Kacerovsky, Hornychova, Jaiman et al
Acta Obstet Gynecol Scand (2024)
(2) "VEGF/VEGFR axis and its signaling in melanoma: Current knowledge toward therapeutic targeting agents and future perspectives"
Malekan, Haass, Rokni et al
Life Sci (2024)
(3) "Soyghurt Potentially Controls the Level of sFlt1 and PLGF in Preeclampsia Maternal Serum-Induced Placental Trophoblast Cell in vitro"
Khairani, Lantika, Ramadhanti et al
J Exp Pharmacol (2024) 16, 111-122
Showing 1-3 of 2944 papers.