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Recombinant Biotinylated Human Mesothelin / MSLN (296-580), Fc Tag, ultra sensitivity (primary amine labeling), Fc Tag, 25µg  

Recombinant Biotinylated Human Mesothelin / MSLN (296-580), Fc Tag, ultra sensitivity (primary amine labeling), Fc Tag, 25µg

Recombinant Biotinylated Human Mesothelin / MSLN (296-580) Protein, AA Glu 296- Gly580, expressed from human HEK293 cells, Fc Tag, ultra sensitivity (primary amine labeling) (MALS verified)

recombinant, human, biotinylated, protein, MSLN,Mesothelin,MPF

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Availability: within 7 days

377,00 €

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Recombinant Biotinylated Human Mesothelin (296-580) Protein, Fc Tag, primary amine labeling(MSN-H826x) is expressed from human 293 cells (HEK293). It contains AA Glu 296 - Gly 580 (Accession # AAH09272 ).

Molecular Characterization
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 59.1 kDa. The protein migrates as 60-68 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with biotins using standard chemical labeling method. A standard biotin reagent (13.5 angstroms) is used in this product.

Biotin:Protein Ratio
Passed as determined by the HABA assay / binding ELISA.

Less than 0.1 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the COA.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Please refer to product data sheet.

Clinical and Translational Updates

(1) "Selection, engineering, and in vivo testing of a human leukocyte antigen-independent T-cell receptor recognizing human mesothelin"
Hiscox, Wasmuth, Williams et al
PLoS One (2024) 19 (4), e0301175
(2) "Mesothelin promotes brain metastasis of non-small cell lung cancer by activating MET"
Xia, Duan, Xu et al
J Exp Clin Cancer Res (2024) 43 (1), 103
(3) "Nonpathogenic E. coli engineered to surface display cytokines as a new platform for immunotherapy"
Romee, Yang, Sheffer et al
Res Sq (2024)
Showing 1-3 of 1685 papers.