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Recombinant Human CD117 / c-kit Protein, His tag, 100 µg  

Recombinant Human CD117 / c-kit Protein, His tag, 100 µg

Recombinant Human CD117 / c-kit Protein, Gln 26 - Thr 516, produced in human 293 cells (HEK293), His tag (MALS verified)

Recombinant Human protein, CD117,SCFR,c-Kit,KIT

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Availability: within 7 days

377,00 €

Mast/stem cell growth factor receptor Kit (c-Kit), a member of the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily, is also known as piebald trait protein (PBT), p145 c-kit, tyrosine-protein kinase Kit and CD117,which contains five Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. CD117 acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, CD117 can activate several signaling pathways. Furthermore, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B.

Recombinant Human CD117, His Tag (CD7-H52H4) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Thr 516 (Accession # P10721-2).
Predicted N-terminus: Gln 26

Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 57.1 kDa. The protein migrates as 66-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg by the LAL method.

>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

See Certificate of Analysis for reconstitution instructions and specific concentrations.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Please refer to product data sheet.

Clinical and Translational Updates

(1) "Intrathyroid thymic carcinoma: clinicopathological features and whole exome sequencing analysis"
Li, Xiang, Li et al
Virchows Arch (2023)
(2) "Unusual breast metastasis of gastrointestinal stromal tumor: A case report and literature review"
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(3) "Morphological and histochemical identification of telocytes in adult yak epididymis"
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Showing 1-3 of 12763 papers.