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Recombinant Human IFN-alpha / beta R1 Protein, Fc Tag, 100 µg  

Recombinant Human IFN-alpha / beta R1 Protein, Fc Tag, 100 µg

Recombinant Human IFNAR1 /IFNAR Protein / beta R1 Protein (Lys 28 - Lys 436), produced in human 293 cells (HEK293), Fc tag

Recombinant Human protein, IFNAR1, IFNAR, CRF2-1, IFN-R-1, IFNAR-1

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Availability: within 7 days

348,00 €

Interferon alpha/beta receptor 1 ( IFNAR1) is also known as Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1 (CRF2-1), Type I interferon receptor 1, IFNAR, which belongs to the type II cytokine receptor family. IFNAR1 /IFNAR contains four fibronectin type-III domains. IFNAR1 associates with IFNAR2 to form the type I interferon receptor. IFNAR1 is receptor for interferons alpha and beta. IFNAR1 can transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.

Recombinant Human IFNAR1, Fc Tag (IF1-H5253) is expressed from human 293 cells (HEK293). It contains AA Lys 28 - Lys 436 (Accession # NP_000620).
Predicted N-terminus: Lys 28

Molecular Characterization
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 73.8 kDa. The protein migrates as 100-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 1.0 EU per μg of the rh IFNAR1 /IFNAR Fc Chimera by the LAL method.

90% (rh IFNAR1 /IFNAR Fc Chimera) and 13% (Human IgG1 Fc fragment) as determined by SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C).


(1) Colamonici O., et al., 1994, Mol. Cell. Biol. 14:8133-8142.
(2) Li X., et al., 1997, Mol. Cell. Biol. 17:2048-2056.
(3) Russell-Harde D., et al., 1999, Biochem. Biophys. Res. Commun. 255:539-544.