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Recombinant Human NKp46 / NCR1 / CD335 Protein, Fc Tag, premium grade, 50 µg  

Recombinant Human NKp46 / NCR1 / CD335 Protein, Fc Tag, premium grade, 50 µg

Recombinant Human NCR1 /NKp46 /CD335 Protein (Gln 22 - Asn 254), produced in human 293 cells (HEK293), Fc tag (MALS verified), premium grade

Recombinant Human protein, NCR1, LY94, CD335, NK-p46, hNKp46

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Availability: within 7 days

377,00 €

Natural cytotoxicity triggering receptor 1 (NCR1) is also known as Natural killer cell p46-related protein (NK-p46), Lymphocyte antigen 94 homolog (LY94), CD antigen CD335, which belongs to the natural cytotoxicity receptor (NCR) family. NCR1 contains two Ig-like (immunoglobulin-like) domains. NCR1 interacts with CD247 and FCER1G. NCR1 / CD335 may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Recombinant Human NCR1 /NKp46 /CD335 Protein, Fc Tag, premium grade(NC1-H5257) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Asn 254 (Accession # AAH64806).
Predicted N-terminus: Gln 22
It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage. When ready to transition into later clinical phases, we also offer a custom GMP protein service that tailors to your needs. We will work with you to customize and develop a GMP-grade product in accordance with your requests that also meets the requirements for raw and ancillary materials use in cell manufacturing of cell-based therapies.

Molecular Characterization
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 53.0 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Less than 0.01 EU per μg by the LAL method.

The sterility testing was performed by membrane filtration method.


>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 10 mM NaCl, pH7.5 with trehalose as protectant.

Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Please refer to product data sheet.

Clinical and Translational Updates

(1) "The inhibitory NKR-P1B receptor regulates NK cell-mediated mammary tumor immunosurveillance in mice"
Al Olabi, Hendy, Alkassab et al
Oncoimmunology (2023) 12 (1), 2168233
(2) "Arabinogalactan G1-4A isolated from Tinospora cordifolia induces PKC/mTOR mediated direct activation of natural killer cells and through dendritic cell cross-talk"
Amin, Shankar
Biochim Biophys Acta Gen Subj (2023) 1867 (4), 130312
(3) "Myeloid-derived suppressor cells inhibit natural killer cells in myelodysplastic syndromes through the TIGIT/CD155 pathway"
Yue, Li, Ma et al
Hematology (2023) 28 (1), 2166333
Showing 1-3 of 1096 papers.