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Recombinant Human ALCAM / CD166 Protein, Fc Tag, 200 µg  

Recombinant Human ALCAM / CD166 Protein, Fc Tag, 200 µg

Recombinant Human CD166 /ALCAM Protein (Trp 28 - Ala 526), produced in human 293 cells (HEK293), Fc tag

Synonym
Recombinant Human protein, CD166, ALCAM, CD6L, KG-CAM, MEMD

More details

CD6-H5259-200

Availability: within 7 days

324,00 €

Background
CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins, which is also known as Activated leukocyte cell adhesion molecule (ALCAM) in human, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat. CD166 is a cell adhesion molecule that binds to CD6. CD166 involved in neurite extension by neurons via heterophilic and homophilic interactions.

Source
Recombinant Human CD166 /ALCAM Protein, Fc Tag (CD6-H5259) is expressed from human 293 cells (HEK293). It contains AA Trp 28 - Ala 526 (Accession # NP_001618).
Predicted N-terminus: Trp 28

Molecular Characterization
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 82.6 kDa. The protein migrates as 95-116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin
Less than 1.0 EU per μg of the rh CD166 / ALCAM Fc Chimera by the LAL method.

Purity
>95% as determined by SDS-PAGE.

Formulation
Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Reconstitution
See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

Clinical and Translational Updates

(1) "Elevated ALCAM Expression Associated with Endotypes and Postoperative Recurrence in Chronic Rhinosinusitis with Nasal Polyps"
Zhang, Xie, Fan et al
J Inflamm Res (2022) 15, 1063-1077
(2) "ALCAM regulates multiple myeloma chemoresistant side population"
Wang, Dan, Luo et al
Cell Death Dis (2022) 13 (2), 136
(3) "ALCAM Makes It All Calm by Inhibiting Apoptosis"
Chen, Parimon
Am J Respir Cell Mol Biol (2022)
Showing 1-3 of 763 papers.