b-NGF, 20 µg

Beta NGF (nerve growth factor) was discovered on account of its ability to regulate growth, differentiation and survival of peripheral neurons during embryo development but it is also involved in a wide variety of functions, such as neuropeptide modulation, wound healing and tissue scar. It serves as ligand for the specific neurotrophin receptors TrkA and p75 receptor.

Synonyms: Beta Polypeptide, NGF, NGFB, HSAN5, Beta-NGF, MGC161426, MGC161428

Protein informations: Nerve Growth Factor-beta, human recombinant produced in E.Coli, is a non-covalently disulfide-linked homodimer, non-glycosylated. The polypeptide chain contains 2 identical 121 amino acids with a molecular weight of two 13.6 kDa polypeptide monomers. The NGF-β is purified by proprietary chromatographic techniques.

Purity: > 95% by SDS PAGE

Biological activity: The ED50, calculated by its ability to stimulate chick E9 DRG neurite outgrowth was found to be < 1.0 ng/ml, corresponding to a specific activity of > 1 x 1.000.000 units/mg.

Product specific literature references:

Nico B, Mangieri D, Benagiano V, Crivellato E, Ribatti D. (2008) " Nerve growth factor as an angiogenic factor." Microvasc Res. 75(2):135-41.

Graiani G, Emanueli C, Desortes E, Van Linthout S, Pinna A, Figueroa CD, Manni L, Madeddu P.(2004) " Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of Type 1 diabetic mice." Diabetologia. 47(6):1047-54. 

Lykissas MG, Batistatou AK, Charalabopoulos KA, Beris AE. (2007)" The role of neurotrophins in axonal growth, guidance, and regeneration." Curr Neurovasc Res.;4(2):143-51.